• ASCOS 2019, 11th Advanced Study Course on Optical Chemical Sensors, Optical (Bio)Sensing for Life Science and Environment, 21-28 July, Bertinoro (MO), Italy.

    Chair: Ambra Giannetti.



iCover pages



Guest Editors

Special Issue "Optical Chemosensors and Biosensors"

Special Issue Editors:
Dr. Ambra Giannetti
Ms. Markéta Bocková
Czech Academy of Sciences, Prague, Czech Republic
Deadline for manuscript submissions: 31 July 2019



Anal Bioanal Chem, vol 405, No. 19, July 2013 Optical Nanosensing in Cell

ABC vol.393, No. 4, March 2009 Optical Sensing in Medicine

ABC vol.381, No. 5, March 2005 Biosensors for Health Care




SPIE Newsroom 

Sensing & Measurement 

Francesco Baldini: Optical monitoring of biomarkers in the body

Real-time measurements of chemical markers provide valuable information for physicians.



Bilitec 2000

In 1988 the idea of measuring bile in the stomach and in the oesophagus via optical fibres was conceived and patented in collaboration with physicians from the University of Florence.


The working principle is based on the spectrophotometric properties of the bile which contains some pigments with definite absorption properties. Bilirubin is the main pigment and it is characterized by an absorption peak in the blue region: therefore it is possible to detect optically the bile in the stomach by optically detecting bilirubm.


The possibility of measuring bile reflux directly measuring the presence of bile represented a winning aspect in comparison with the traditional techniques (pH-metry, cholescintigraphy, bile acid assessment in aspirates); on the contrary the new technique had to overcome the traditional "cultural' barriers constituted by the conservative attitude of clinicians concerning any innovative technology.


The realization of the first laboratory prototype demonstrates the feasibility and validity of the proposed optical method.

Then many years were necessary to arrive at the definitive and marketable product, Bilitec 2000, commercialised by Medtronics up to 2007 and now by EBNeuro.