LAMBDA

Lambda (Opto-electrochemical dual-sensing mode fiber optic devices for label-free small clinical targets monitoring) project aims at the design, development and assessment of lossy mode resonance (LMR)-assisted optical sensors with improved performance for the detection of small-size biomolecules by means of a dual-sensing mode operation: optical and electrochemical changes in refractive index (RI) and in charge transfer, respectively. A label-free–based approach permits the real-time monitoring of binding kinetics without using complicated and time-consuming labelled methods. By taking advantage of LMR sensors, the enhanced light-matter interaction is underpinned by a stack of metal-oxide nanometer-scale films of low and high RIs. Moreover, the orientation of surface-immobilized capture elements plays a critical role in the biosensing performance. Therefore, an ad hoc developed strategy of surface functionalization permits the binding sites of the immobilized receptor to be directed toward the solution phase. In addition, the biofunctionalization is optimized by considering other properties (size and charge of both receptor and target), which may potentially affect both optical and electrochemical responses. The device is preliminary tested for the detection of gold standard biomolecules to pinpoint the general performance. The electrical conductivity of metal-oxide films allows the realization of parallel electrochemical identification of biomolecules, which can foster further information on the sensing mechanism. Finally, some Alzheimer’s disease markers are selected to assess the dual-mode operation of the proposed device toward future thrilling applications in the biomedical fieldon of the target analyte, until they are fully and safely resorbed on-demand, using an external trigger.  collected by the waveguide devices.

Role: Coordinator

Activity period: 2025-2027 

EVANESENSE

Evanesense (Bioresorbable Optical Sensors For In-Vivo and In-Situ Monitoring Of Chemotherapeutic Drugs) is a project which proposes a new sensing technology for in-vivo bioresorbable sensing of analytes of clinical interest (e.g., drugs, biomarkers) that exploits optical devices and synthetic receptors fabricated with materials that dissolve with biologically safe byproducts. The sensors are designed to be implanted in the body to monitor, in-vivo, in-situ, and in real-time, the concentration of the target analyte, until they are fully and safely resorbed on-demand, using an external trigger. As a case study, the activity is focused on chemical sensors based on two bioresorbable optical devices with different operating principles (resonant photonic crystals and waveguides) functionalized with biocompatible molecularly imprinted polymers (MIPs) designed as specific receptors for doxorubicin (d-MIP). Doxorubicin (doxo) is a fluorescent chemotherapeutic drug commonly used for the treatment of several cancers, including breast and skin cancer. MIPs are polymeric receptors fabricated in the presence of a target molecule acting as template, which is then removed from the polymer leaving cavities complementary to the template, thus making MIP capable to specifically rebind the target. The sensors are implanted on the back of an animal model, in the subcutaneous tissue, and doxo concentration is monitored by measuring, through skin, the fluorescence intensity of doxo (emission at 590 nm where skin has good transparency) bound to d-MIP and amplified by the resonant photonic crystal or collected by the waveguide devices.

Role: Partner

Activity period: 2025-2027 

Pump-priming UK-EU

Fibre-Based Microfluidic Sensing For Pathogen-Relevant Sensing

The project aims to develop a new type of diagnostic sensing platform that combines micro-scale fluid handling with a high aspect ratio flat silica optical fibre. This approach allows very small volumes of biological samples to be guided across a sensing region and analysed optically in real time. The work is focused on early-stage enabling technology rather than a finished medical device. We establish the basic design rules, feasibility, and performance limits using safe laboratory surrogate samples rather than patient material. The collaboration links UK photonics expertise at the University of Southampton with complementary capability in microfluidics and biosensing at CNR-IFAC (Italy) to build a joint foundation for a future Horizon Europe bid in infectious-disease diagnostics. The long-term motivation is to create compact, manufacturable sensing heads that could, in the future, support rapid testing in healthcare and outbreak-response settings.

Role: Partner

Activity period: 2026-2027 

THE, Tuscany Health Ecosystem

The Spoke 4 of the Tuscany Health Ecosystem (THE) project, has been devoted to the development of advanced nanotechnologies for diagnosis and therapy (Spoke 4). In particular:

1) a platform using long period gratings (LPGs) was developed for the detection of FKBP12, one of the FK binding proteins (FKBP) at the crossroad of important metabolic pathways, in collaboration with the Department of Chemistry of the University of Florence who developed a novel recognition element for FBKP12 with a chemical structure mimicking the natural FBKP12 binders, Tacrolimus and Rapamycin

2) PEGylated lipid nanoparticles loaded with MBs for survivin to be tested in human lung adenocarcinoma A549 cells were developed in collaboration of the University of Siena

3) a novel promising strategy for sensitive SERS-based microRNA detection was realized by exploiting a signal-off mechanism by means of a labelled MB as the oligonucleotide biorecognition element immobilized on the SERS substrate: the MB tagged with carboxy-X-rhodamine (ROX) as Raman reporter is employed and the distance between the label and the SERS surface is distinctly changed upon hybridization with the target microRNA, resulting in a measurable SERS signal variation.

Role: CNR representative for Spoke 4

Activity period: 2022-2026

BOHEMIAN

The main objective of BOHEMIAN (Versatile hybrid in-fiBer Optical-electrocHemical systEMs for wIdely Applicable biosensing) consisted in the development of integrated hybrid opto-electrochemical sensors. Both analytical approaches have their own advantages and disadvantages, and each of them is usually used for a specific application depending on the analyte type, molecular weight (MW), concentration range. At the same time the two methods are complementary: for example, one can be beneficial at low target concentrations, while the other can offer better performances for high target concentrations. With the simultaneous application of optical and electrochemical methods in hybrid opto-electrochemical sensors we have the possibility to overcome the limitations of using only one of them. The advantages offered by the hybrid transduction system are coupled to the benefits deriving by the use of aptamers as bioreceptors: if all the noteworthy characteristics of aptamers are coupled to an appropriate transduction tool, an unthinkable amount of possibilities is open up to develop biosensing methods for any imaginable target. The design of all the technological aspects in the system has been performed in the light of developing, in the future, a flexible platform, not only for an easy change of the analyte panel but also looking at an easy scale up of the system  Due to the easy in the fabrication part, our project is the basis for the future development of low-cost platforms that will be potentially industrialized with low efforts  The versatility of the hybrid opto-electrochemical sensors are applied to the detection of target molecules in different MW ranges and significant in various fields, ranging from agri-food to health. The research proposed in the present project is opening the possibility to develop a new generation of biosensors based on a wide working range and versatility due to the coupling of electrochemical and optical detection, and high selectivity and, again, high versatility, guaranteed by the aptamer receptor layer.  The fulfilment of the BOHEMIAN goals are able to produce a general advancement of knowledge in the science of sensors and a strengthening of the scientific community, together with a significant social impact and a consistent economic impact on the global society.

Role: Coordinator

Activity period: 2023-2026

FOCAL

At present, early diagnosis and treatment of cancers through biomarker detection in body fluids represents one of the greatestchallenges in biomedical research given its health, social and economic impact  Currently, the gold standard in detection of biomarkers relies on complicated, operator-dependent and time-consuming tests that require large volumes of samples and reagents (e g , ELISA, immunofluorescence, western blotting, immunodiffusion, PCR, flow cytometry, etc ). Other approaches (mostly based on surface plasmon resonance, SPR) are present on the market but do not always ensure the required level of sensitivity, data consistency, reliability, and accuracy Therefore, there is still a strong unmet need to develop a reliable, compact and operando monitoring platform with low limit of detection (LOD) of sub-femtomolar range for cancer diagnosis through a simple human biofluid test (liquid biopsy). The project FOCAL (Fiber Optics sensors as a platform for CAncer diagnosis and in vitro modeL testing) aimed at developing a biophotonic platform based on optical fiber sensors combined with functional nanomaterials and microfluidics for non-invasive early diagnosis of cancer. The outcomes allows going beyond the current state related to point-of-care testing technology, paving the way for the development of outperforming biosensing platforms  For these purposes, we use a multidisciplinary approach which leverages and integrates the consolidated and complementary expertise in optics, biophotonics, material science, nanomaterials, as well as biomolecules conjugation, and optical detection based on fibers and cancer cellular biology of 2 established research units (CNR and POLITO).  Within this integrated collaborative network, we exchange researchers and knowledge to fulfill our scientific vision, thus generating new and effective ways to exploit nanomaterial-based optical detection platforms to impact not only at a scientific level, but also at an economic and societal one.

Role: Coordinator

Activity period: 2023-2026

BIOEMC

BioEMC (Biochips for Emerging Micro-Contaminants) aimed at developing and validating compact and cost-effective biochips for detecting analyte concentration in water, through light excitation and highly sensitive detection at the single-photon level. BioEMC targets Emerging Micro-Contaminants (EMCs) in surface, sediment and waste water. Nevertheless, BioEMC bioreceptors are easily adaptable also to other targets.  Into the biochip, a solution flows through a microfluidic structure in contact with a light-guiding media, where an optical interaction is exploited to inspect the presence of selected EMCs (which absorb the incoming light and/or emit luminescence and fluorescence stimulated light) by means of on-chip optical detectors, specifically measuring both absorbed/scattered light and fluorescent light. Single Photon Avalanche Diode (SPAD) detection array chips provides the ultimate quantum sensitivity  BioEMC project relies on 4 enabling breakthroughs provided by the three partners 1) ION-DIFFUSED WAVEGUIDES on glass substrate will evanescently couple the excitation light to suitably functionalized channels for EMC bioassays, occurring along microfluidics possibly made in polydimethylsiloxane (PDMS). The optical coupling leads to light absorption/scattering change along the waveguide length due to the accumulation of target molecules as a consequence of their interaction with the immobilized bioreceptors (either antibodies or aptamers), specifically developed to interact with the selected micro-contaminants in a direct bioassay  The optical coupling enable the excitation of the biosensing layer and the related fluorescence emission from intrinsically fluorescent antibodies and also from not auto-fluorescent aptamer-based analytes. 2) APTAMERS, which specifically recognize the target molecules of micro-contaminants, are engineered to work as beacons, switching their light on-and-off depending on the interaction with the target analyte. This allows a direct bioassay development, so to completely avoid further assay manipulation, commonly used in other fluorescence–based bioassays. 3) ON-CHIP PHOTODETECTOR deposited onto the biochip’s glass substrate, to measure the intensity of light at the end of the waveguide to quantify the attenuation along the waveguide, dependent on the occurring bioassay. 4) MICROELECTRONIC SPAD chips provides ultimate single-photon detection sensitivity and time-domain filtering at the nanosecond level, by employing pulsed light excitation and time-gating. In fact, absorption/scattering effects at the same excitation wavelength as well as luminescence/fluorescence signals at longer wavelength than the excitation one are extracted from the more intense excitation light through time-domain filtering, with no need of bulky optical filters, usually implemented in commercial instruments, which add complexity, cost and bulkiness.

Role: Partner

Activity period: 2023-2026

POINTOFCARE

POINTOFCARE (Point-Of-Care electroanalytical platform for the detection of bacteria and antibiotic resistance) aimed to the development of an electroanalytical Point-Of-Care (POC) platform for the detection of model gram-negative and gram-positive living bacterial cells and antibiotic resistance for the potential use at healthcare settings. The electrochemical detection is based on the bacterial metabolism, which has the potential to reduce the detection time compared to optical measurements. The following key targets are addressed:

1) fabrication of an electroanalytical module (EAM) for the on sensor capture and electroanalysis of living bacteria via metabolic activity indicators by using inkjet printing;

2) bacteria capture and culture onto inkjet-printed porous polymeric layers containing specific bacteria recognition elements; the sensitivity of bacterial cell detection is enhanced by the enrichment of bacterial cells multiplying inside the capture layer near the sensor surface;

3) implementation of a microfluidic module (MFM) for the automated flow of sample and reagents;;

4) implementation of a heating module (HM) containing thin film heaters and temperature sensors for on sensor bacteria culture at 37 °C;

5) design of a laboratory prototype POC platform integrating the EA, MF and the H modules, together with the electronic controls for temperature, pumping of fluids and electroanalysis;

6) bacteria detection realized by means of electrochemical detection of the continuous consumption of an electro-active bacterial metabolic indicator and by surface plasmon resonance (SPR).

Role: Partner

Activity period: 2023-2026

PRONANO4BIO

The ability to tailor biological macromolecules continues to fascinate the scientific community since it brings broad and useful potential applications. Currently, most of the hybrid inorganic-biomolecules systems are based on metal nanoparticles (NPs) and self-assembled monolayer (SAM) modified electrodes as tools to assure the protein assembly and to support their absorption and electrical connection in solid phase. In particular, improved performances in terms of surface-active and enhanced electron transfer (ET) process were rationalized considering the gold NPs as relay for shuttling electrons between electrode and enzyme-active sites. Despite some interesting results, a clear understating of the correlation between properties and performances is still far from being achieved affecting the potentiality and application of these bio-hybrid architectures. ProNano4Bio (Engineering Functional Metal Nanocluster-Protein Architectures for Bio(sensing and catalytic) applications) aimed at developing new generation of smart hybrid bionanomaterials, based on atomically precise metal NCs, to investigate in depth the structure-function relationship among metal nanostructures, biomolecules, and surfaces  The outcomes allows going beyond the grossly averaging analysis related to the use of polydisperse larger nanomaterials, thereby paving the way for the developing of outperforming singlet-oxygen photosensitizers, bioelectrocatalysts, and biosensors. For these purposes, we use a multidisciplinary approach which involves and integrates the consolidated and complementary expertise in electrochemistry, photochemistry, NCs synthesis, as well as biomolecules conjugation, and optical detection based on fibers of 4 established research units (RU-PD, RU-MO, RU-VE, and RU-CNR). Within this integrated collaborative network, we exchanged researchers and knowledge to fulfil our scientific vision, thus generating new and effective ways to exploit NCs-based bionanomaterials to impact not only at a scientific level, but also at an economic and societal one.

Role: Partner

Activity period: 2023-2026

SEROTONIN

A near future, in which green and mimetic entities will be able to replace the use of antibodies (Abs) in bioanalytical chemistry and diagnostics (including immune-based therapeutics), is mandatory. This is what the EU is asking us from the 2010/63/EU Directive on the protection of animals used for scientific purposes, limiting their use only “where a non-animal alternative exists”. Despite the many attempts in flanking Abs production by new technologies based on Animal-Friendly Affinity reagents, these did not lead to a decisive turning point, and Abs remain almost the only choice to address most of the (bio)analytical issues based on biomolecular recognition. Among possible scenarios, mimetic receptors appear promising, ideally guaranteeing high stability and long shelf-life, reduction of batch-to-batch variability and cost production, also covering the need for receptors for toxic and non-immunogenic targets. Strongly convinced by our recent results, we have great expectations about a class of molecularly imprintable biopolymers, with high potential to function as Abs, hopefully better. Inspired by Nature, they derive directly from the polymerization of the endogenous neurotransmitters (NTs) dopamine and norepinephrine. In presence of a template, these NTs spontaneously polymerize while embedding it in the polymer network, leading to adherent nanofilms  We demonstrated that these imprinted polyNTs can be efficiently prepared via “epitope imprinting” against a plethora of peptides and proteins to obtain mimic receptors  This peculiar class of “soft” molecularly imprinted polymers, called Imprinted Bio-Polymers (IBPs), are temperature resistant, reusable, tunable in size and optical properties. Moreover, they are endogenous, safe, biocompatible/biodegradable, and low cost. The project SEROTONIN (Discovering the secret world of polyserotonin for green molecular imprinting and its application in bioanalytics) aimed to expand our knowledge on a third NT, i.e. serotonin. Aside from its involvement as a monomer in important physiological processes, its potential ability in forming the related polymer (polyserotonin, PSE) is still a completely neglected topic in literature. Only recently, the first experimental evidence in this sense was published. This project aimed to investigate and compare, for the first time, PSE to the previous ones to develop a future generation of Abs-free (bio)assays. PSE-based IBPs are coupled to two optical platforms at the forefront of label-free biodetection: surface plasmon resonance and long period fiber gratings for characterization and validation. Supervised and unsupervised Machine Learning approaches are applied to develop an ex-ante selection method of the peptide templates (epitopes). This lead not only to understand the imprinting mechanisms evoked by these systems more in depth, but also to do a leap forward in the application of these materials at research and health industry.

Role: Partner

Activity period: 2023-2026

Development of novel DNA-based analytical platforms for the rapid, point-of-use quantification of multiple hidden allergens in food samples

The overarching objective of the proposed research program (PRIN 2017) is the development of sensing devices suitable for the detection of any of a wide range of allergens in food samples. By joining multidisciplinary expertise, the project proposes the development of novel electrochemical or optical sensing platforms all based the used of synthetic DNA as both recognition element (i.e. aptamers) or scaffold that will support the rapid (15 min), point-of-use quantification of multiple allergens. The Chemical & Biochemical Optical Sensor Group will lead the optical sensors activity by designing a novel point-of-use optical-based platform for multiple allergen detection for both fluorescent and chemiluminescence outputs. The methodology for the implementation of the fluorescence-based assays will be centered on the optimization and characterization of an optical setup for multi-allergen detection. The heart of the optical platform will be a biochip constituted by microchannels, each of one devoted to the measurement of a different analyte. The chip is interrogated in an optoelectronic platform with simultaneous excitation and fluorescence collection by exploiting fluorescence anisotropy. This optical setup will significantly reduce time of analysis due to the parallel fluorescence excitation and read out of all the channels of the microfluidic chip.

Role: Partner

Activity period: 2018-2021   

FASPEC

FASPEC (Fiber-based planar antennas for biosensing and diagnostics) is an international project within the action ERANET COFUND Photonic for sensing. The ability to deliver critical data for pathogen determination in a timely manner makes high-performance diagnostic tools a future key component of the healthcare system. Although fluorescence-based approaches are widely available, conventional read-out optics is bulky, not flexible and often lacks of high sensitivity. Nanophotonics-based sensing promises to build on the advantages of optical sensing while overcoming its limitations, providing better sensitivity as well as easier integration into affordable devices and disposable units. We have recently developed a planar optical antenna that can largely improve the collection efficiency by beaming the emission of molecules into a narrow cone. The project aims at translating these findings into a fluorescence-based molecular assay for in-vitro diagnostics and on the integration of the optical readout scheme into an automated platform. The key photonic innovation is the replacement of the bulk optics with a suitably designed photonic chip. The latter shall direct fluorescence towards the sensor head, enhancing the fluorescence limits of detection by orders of magnitude. The bioassays and the platform validation will focus on sepsis, which is a common hospitalization disease with high mortality rates. The photonic chip will be functionalized with biological recognition elements for selected target molecules, e.g., proteins and microRNA as sepsis biomarkers. Our aim is to rapidly translate a scientific achievement into an innovative technology, where large sensitivities are attained in a compact and low-cost device, and to provide new tools to diagnose sepsis, a major challenge of the healthcare system.

Role: Partner

Activity period: 2018-2021   

Information at: http://nano-optics.physik.uni-siegen.de/research/projects/faspec/

SAFEWATER

SAFEWATER (On chip whispering gallery mode optical microcavities for emerging microcontaminant determination in water) is an international project within the action ERANET COFUND Photonic for sensing. The project focuses on the design and realization of a novel, portable platform based on optical WGM microbubble resonators able to perform a label-free multiplexed detection and determination of emerging microcontaminants (EMCs) in different water matrices with high sensitivity and extremely low limit of detection. Due to the multidisciplinary nature of the project, a strong synergistic interaction among all the involved partners with different expertise in chemistry, physics and engineering is requested in order to develop each basic block of the integrated final instrument. The consortium gathers together research organizations and industrial representatives coming from Poland, Portugal and Tuscany.

Role: Coordinator

Activity period: 2018-2021   

Information at: http://www.iet.unipi.it/g.barillaro/safewater/Home.html 

OPTIMO

OPTIMO (Multichannel optical fibre device for simultaneous manometry, pH-metry and bilimetry in oesophagus) is an international project within the action ERANET COFUND Photonic for sensing. The target of the present proposal is the design, implementation and characterization of a portable device based on an all-optical technology capable to perform simultaneously oesophageal manometry, pH-metry and bilimetry. Pressure measurement along the oesophagus is performed with an array of optical fibre gratings, which ensures the monitoring along a length of about 30 cm with high spatial resolution. The sensors for the measurement of pH and bile are based on the change of absorption caused by the parameter under investigation. In the case of pH, an acid-base indicator that changes its absorption as a function of pH is immobilized on controlled pore glasses suitable coupled to plastic optical fibres. As for bile detection, the measurement is based on the direct absorption of bilirubin, the main biliary pigment, and a bundle of plastic optical fibres carries the signal. Clinical assessment of the realized device on patients is scheduled in the last year of the project.

Role: Coordinator

Activity period: 2018-2021   

Information at: http://www.optimo-project.eu

CIREBI

CIREBI (“Componenti Intelligenti con Reticoli di Bragg Integrati") is a POR CREO FESR 2014-2020 research project funded by theTuscany Region. Aim of the project is the development of two "smart" components equipped with FBG based sensors network for the continous real time monitoring of deformations and temperature. The two components will be: 1) a standard Eurocard PCB electronic board with FBGs embedded for the temperaure monitoring; 2) a fiber reinforced polymer composites cylinder, part of a low pressure anechoic chamber, equipped with an FBGs network for the monitoring of the deformations during the creation of the vacuum.

Role: Partner

Activity period: 2018-2020

HEMOSPEC

HEMOSPEC (“Advanced spectroscopic hemogram for personalized care against live threatening infections using an integrated chip assisted bio-photonic system”) is a FP7 project with the objective of development of a highly innovative technological platform for early, fast and reliable medical diagnosis of infectious diseases using only minimal amount of patient’s blood.

Role: Partner

Activity period: 2013-2018

Research Line: Biophotonic diagnostic

Information at:

http://www.hemospec.eu/

https://www.youtube.com/watch?v=GLURkAY1ESY

NANOMAX-ENCODER

NANOMAX-ENCODER (“Engineering Nanostructures for Cellular imaging and for intracellular delivery of Optically active Drugs for cardiac hypERtrophy”) is a CNR flag project coordinated by IFC-CNR, within the flagship project Nanomax.

Role: Partner

Activity period: 2012-2018

Research Line: Optical Nanosensing

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Improving Therapy for Breast Cancer and Melanoma by Transcriptome-Methylome Profiling, Integrative Network Inference, and Design of Novel Theranostic Tools

Improving Therapy for Breast Cancer and Melanoma by Transcriptome-Methylome Profiling, Integrative Network Inference, and Design of Novel Theranostic Toolsa.

Role: Subcontractor

Activity period: 2015-2019

Research Line: Optical Nanosensing

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  SENS4BIO

SENS4BIO (“Microrisonatori Optofluidici Ultra-Sensibili di Tipo “Flow-Through” per Applicazioni Biosensoristiche”) is a national “Future in Research” MIUR project devoted to the development of ultrasensitive flow-through optofluidic micro-resonators for sensing applications, coordinated by the Dept of Information Engineering of the University of Pisa.

Role: Partner

Activity period: 2013-2017

Research Line: Optical Resonators

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   NANODEM

NANODEM  (“NANOphotonic DEvice for Multiple therapeutic drug monitoring”) is STREP FP7 project which aim is the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the measurement of immunosuppressants and related metabolites in transplanted patients.

Role: Coordinator

Activity period: 2012-2016

Research Line: Biophotonic diagnostic

Information at:

• http://nanodem.ifac.cnr.it/

• https://www.youtube.com/watch?v=-CCDvi-R0hg

• http://www.cnrweb.tv/nanodem-dopo-il-trapianto-per-un-monitoraggio-costante-dei-farmaci/

   CAREMAN

CAREMAN (“HealthCARE by Biosensor Measurements And Networking”) is an European FP6 Integrated Project aimed to the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the for the determination of biomarkers.

Role: Partner

Activity period: 2006-2011

Research Line: Biophotonic diagnostics

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   CLINICIP

CLINICIP (“Closed Loop Insulin Infusion for Critically Ill Patients”) is an European FP6 Integrated Project with the objective to develop a glucose monitoring and control system for critically ill patients.

Role: Partner

Activity period: 2004-2007

Research Line: Biophotonic diagnostic

Information at:

http://cordis.europa.eu/project/rcn/71227_en.html

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  ARTEMIDE

ARTEMIDE (“Autonomous Real Time Embedded Multi-analyte Integrated Detection Environment”) is a PRIN national project with the objective to develop a fully integrated lab-on-chip system for the early diagnosis of viral infections.

Role: Partner

Activity period: 2013-2016

Research Line: Biophotonic diagnostic

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   NANOCELL

NANOCELL (“Optical Nanosensors inside cells) is a regional project ( PAR FAS Regione Toscana Linea 1.1.a.3) which aim is the

Role: Coordinator

Activity period: 2011-2013

Research Line: Optical Nanosensing

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   Bilateral Project S&T Programme Italy-India

Bilateral Project S&T Programme Italy-India  (Joint Research Proposal under CNR, Italy – CSIR, India) is an international project with the objective to develop a Long Period Grating based immunoassay for biosensing applications.

Activity period: 2012-2015

Research Line: Optical Fiber Gratings

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  SONDA

SONDA (Optical device for the combined measurement of pH and biliary content in gastroesophageal apparatus) is a regional project coming from a contract with the company Cecchi srl with the objective of the realisation of an optical device equipped with a single optical fibre catheter capable of the simultaneous measurement of bile containing refluxes and pH.

Activity period: 2012-2013

Research Line: Biophotonic diagnostics

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  COMOCADOF

COMODACOF(“Continuous Monitoring of Gastric Carbon Dioxide with Optical Fibres”) is an European research project with the objective of developing an optical fibre sensor for the continuous monitoring of the partial pressure of carbon dioxide in the stomach. The

Role: Coordinator

Activity period: 1996-2000

Research Line: Biophotonic diagnostics

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